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Catechins are part of a larger group of compounds called polyphenols

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Diffuse pigmentation includes physiologic pigmentation, pigmented hairy tongue, and medication-induced pigmentation

Despite early interest, it has not progressed through formal clinical development and remains a research compound

Peptide therapy has emerged as a compelling option, with treatments increasingly appearing in aesthetic practices and clinics

Notably, most of the serum metabolites were negatively correlated with Ileibacterium , Faecalibaculum , Allobaculum , Candidatus Saccharimonas , and Akkermansia , while positive correlations were predominantly observed with Desulfovibrio and Colidextribacter