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Gut hormone PYY(3-36) physiologically inhibits food intake
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Ozempic is typically initiated at 0.25 mg weekly for four weeks (a non-therapeutic starter dose to improve tolerability), then increased to 0.5 mg weekly
There is growing evidence that GLP 1 receptors are commonly expressed in the pancreas (, and cells), lung, heart, kidney, stomach, intestine, pituitary gland, skin, vagal ganglia, and multiple regions of the central nervous system (including brainstem, hypothalamus, hippocampus and cortex), determining the diversity of GLP 1 physiological actions
Small, protein-rich meals spread throughout the day work best for managing GI side effects
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