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In this process, the nanozyme can catalyze GSH into glutathione disulfide (GSSG) by oxidation of H 2 O 2 , realizing tumor-specific catalytic therapy with response to the TME featuring overexpressed GSH and H 2 O 2 (Yin et al., 2019)
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Combination therapy: an upcoming paradigm to improve kidney and cardiovascular outcomes in chronic kidney disease
It has been reported that suppression of EMT mediated by histone deacetylase SIRT1 gene silencing or pharmacological inhibition consequently decreases ferroptosis, which further suggests that EMT promotes ferroptosis through epigenetic regulation pathways (Lee J
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Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload
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