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Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh WS, Isaacs WB and Nelson WG

Nature Reviews Endocrinology, 19(3), 157171

The target names were standardized using the UniProt database

Published preclinical studies use it as a chemical tool to investigate NNMT activity, nicotinamide metabolism, cellular methyl-donor balance, NAD-related pathways, and adipocyte biology in cell and animal models

Nicotinamide is the precursor for NAD+ salvage the recycling pathway that regenerates NAD+ from the nicotinamide produced by sirtuin and other NAD+-consuming reactions

Higher doses or combination infusions that include additional nutrients naturally extend the session length