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The most significant published evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), which demonstrated substantial dose-dependent weight loss in adults with obesity over 24 weeks, with continued weight reduction observed at 48 weeks

Others suggest it modulates gastric motility through effects on myenteric plexus neurons

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The Medicines and Healthcare products Regulatory Agency (MHRA) becomes involved only if medicinal claims are made, classifying such products as 'borderline substances'

Users take this pill in the morning on an empty stomach and wait half an hour before eating or drinking

These tiny vesicles are released by cells