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although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters ( MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)
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37 (3), E124
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Typically, the nausea, vomiting and facial flushing are more prominent There are also reports of priapism [prolonged erections] and yawning, Dr Frew said
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