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Moderate ROS can reinforce PI3K/AKT/mTORC1 activation, whereas excessive accumulation induces oxidative stress and inactivates key components, shifting the balance toward cell death [48, 49]

Pediatr Res 19:459466 Frye RE, Melnyk S, Macfabe DF (2013) Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder