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This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

This is adequate for peripheral metabolic effects like appetite suppression and insulin sensitization, but it may limit the full potential of central GLP-1 receptor activation

5 Footnotes BMI=body mass index

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42.1% of participants lost more than 15% of starting weight