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Research Dosing Protocols Based on clinical trial data, most researchers follow a gradual titration protocol: TYPICAL ESCALATION SCHEDULE: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: 12mg weekly (maintenance dose) This gradual increase helps minimize side effects while allowing the body to adjust to the compound

Nausea and GI effects are most pronounced during the first 2 to 3 weeks at each new dose level, then typically moderate

BMJ Open Diabetes Res Care (2020) 8:e001279

PMID 36216945, DOI 10.1038/s41591-022-02026-4, STEP 5

Shape confirmed this was likely not a mistake but a clear decision by Novo

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