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The biomarker changes (lower blood pressure, better lipid profile) are favourable and create a reasonable prior expectation, but the dedicated cardiovascular outcomes trial (TRIUMPH-Outcomes) is not expected to report until late 2027 or early 2028

Have your blood pressure checked periodically so your clinician can adjust medications as your weight changes

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While this allowed for a broader synthesis of available evidence, observational studies are more susceptible to residual confounding and selection bias, which may influence the observed associations

Sun et al., 2016b

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