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In a randomized trial in 30 cancer patients undergoing immunotherapy with interleukin-2 (IL-2), there were significantly fewer cardiac complications in those who received 1000 mg oral L-carnitine daily in addition to IL-2 compared with those who received IL-2 alone (Lissoni 1993)

These therapeutic strategies possess high selectivity, especially when activated by GSH localized in the tumor [80]

DFO is not orally active and needs to be administered intravenously or subcutaneously (Merlot et al., 2013)

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