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The published preclinical context is rodent injury models and in-vitro cell systems

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SIDE EFFECTS DSIP is generally well-tolerated in research protocols due to its function as a natural neuro-modulator rather than a systemic sedative

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The compound has been shown in cell-based research to upregulate VEGFR2 transcript levels, increase phosphorylation of downstream signalling intermediates after VEGF stimulation, and enhance endothelial tube formation in matrigel assays

Unfortunately, even with these mercury concentration changes there has been limited or no clinical improvement in the patients, with numerous cases reporting continued patient deterioration, in some cases to permanent disability or death [Citation12, Citation13, Citation16, Citation45, Citation59, Citation66]