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The black box warning on GLP-1 receptor agonists stems from animal studies showing C-cell hyperplasia and medullary thyroid cancer in rodents
After opening a vial, reconstitute the entire contents immediately or re-seal with desiccant packs and return to 20C within 60 seconds of exposure to room air
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At the G-site, tyrosine (alpha, mu, pi, and sigma isoenzymes), serine (kappa), or cysteinyl residues (theta) are involved in GSH binding through hydrogen bonding
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