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reducing the risk of decreased glomerular filtration rate, end-stage renal disease, and cardiovascular mortality in patients with diabetes mellitus and chronic kidney disease

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Future directions include the need for well-designed RCTs with large sample sizes to confirm findings, assessment of long-term safety and tolerability in patients with HS, and further research into the molecular mechanisms by which GLP-1 RAs affect HS pathophysiology

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a The study by Piotrowski et al

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