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Weight Loss: Average weight loss in the LEAD trials was 2 kg to 3.24 kg, with the majority of the reduction noted in the first 4 months of therapy, but tending to be sustained throughout the remaining period of the studies

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Pediatr.Res 1982;16(2):89-91

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(3) trigger signal transduction by binding to iron regulatory proteins (IRPs), which translocate to the nucleus and bind to iron responsive elements (IREs), allowing the modulation of genes important in iron metabolism, such as the gene encoding for TrfR and DMT1