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Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]
In Vitro 52 PinheiroJ.BatesD.DebRoyS.SarkarD.R Core Team (2009)
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