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These include suppressing hepatic gluconeogenesis, amplifying insulin secretion (glucose-dependent), and inhibiting glucagon release ( Liraglutide and semaglutide, which stimulate GLP-1 receptors, enhance the efficacy of incretin function and result in lowered fasting and postprandial glucose levels ( The patient underwent treatment for 4 months, initially using a well-tolerated dose of 0.25 mg of semaglutide weekly for 1 month before increasing it to a maximum dose of 0.5 mg
Mice were anaesthetised with isoflurane (Isoflurin 1000 mg/ml, Axience, France) and positioned in a stereotaxic frame (Phymep Model 940 Small Animals)
Diabetes Care 2001;24:631636
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