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This robustness was abolished in the zwf1 yeast background where the oxidative pentose phosphate pathway as the major NADPH source of the cytosol is impaired and cannot be regulated and in mammalian cells starved for glucose

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Lab studies show a thin line between helpful and harmful dosesNAM helps cells stay alive at about 5 mM but kills them at doses above 20 mM [4]

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Rather than blocking a single cytokine outright, many peptides modulate upstream regulatory pathways

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