It is frequently indicated for fatigue, numbness, and neurological discomfort due to B12 deficiency
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There are sections dedicated to joint and tendon health, brain health, sleep and arthritis
The mechanism is still unclear, but one oft-cited study of women who were overweight or obese and also had prediabetes found that NAD supplementation with nicotinamide mononucleotide (NM), an NAD precursor, for 10 weeks improved insulin sensitivity
Some individuals also report using microdoses for appetite modulation without seeking the substantial weight loss associated with higher doses, or as a gentler introduction to the medication before escalating to standard doses