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Phase 2 trials confirmed no changes to fasting glucose, insulin, or IGF-1 levels after 12 weeks of AOD-9604 dosing, making it mechanistically distinct from full growth hormone therapy

AAV Mediated Exendin-4 Gene Transfer to Salivary Glands to Protect Subjects from Diabetes or Obesity

Inflammatory dysregulation sits at the root of certain obesity patterns and at the root of mast cell activation, POTS, and chronic inflammatory illness

Shibata S, Endo S, Nagai LAE, E HK, Oike A, Kobayashi N, Kitamura A, Hori T, Nashimoto Y, Nakato R, Hamada H, Kaji H, Kikutake C, Suyama M, Saito M, Yaegashi N, Okae H, Arima T (2024) Modeling embryo-endometrial interface recapitulating human embryo implantation

We established a D-galactose-induced aging model in randomly selected male and female mice through intraperitoneal injections of D-galactose (200 mg/kg/day, MCE, HY-N0210), starting at 8 weeks of age for 8 weeks

McKinnon et al report that tertiary care centers have the best results