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This extended signaling allows for a steady, basal increase in growth hormone and IGF-1 levels without causing the aggressive spikes that disrupt natural endocrine rhythms

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

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doi: 10.1089/ars.2016.6737 76 HovattaI.TennantR