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The National Academies of Sciences, Engineering, and Medicine suggests general adequate intake of about 3.7 liters (125 ounces) daily for men and 2.7 liters (91 ounces) for women from all beverages and foods combined, though patients with heart failure or kidney disease may have fluid restrictions

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doi:10.1038/273120a0

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These medications are only available through specialist weight-management services on the NHS, following dietary, exercise, and behavioural interventions, and must meet NICE-defined stopping rules

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