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In a recent study, Newsome et al

The most frequently reported adverse events were gastrointestinal in naturenausea, diarrhoea, vomiting, and constipationconsistent with the known side-effect profile of GLP-1 receptor agonists

GLP-1/GIP, GLP-1/glucagon, and even triple agonists are the dominant focus, though the spectrum extends to other mechanisms as wellamylin, GIP antagonism, NK2 receptor agonism, and more, said DiMarchi Looking further ahead, DiMarchi sees potential for oral therapies, including oral peptides

Even small adjustments in IGF-1 LR3 dosing can significantly affect physiological response