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Total spending on GLP-1 medications in the US skyrocketed by over 500% from 2018 to 2023, rising from $13.7 billion to $71.7 billion

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7 However, a letter to the editor showed that, had the meta-analysis included trials for off-market GLP-1RAs, which still represent valuable data, the association would not have been significant

The gallbladder hormone-2 (CCK2) receptor is overexpressed in MTC, small cell lung cancer, and other neuroendocrine tumors (Refardt et al., 2021) and is considered a promising new target for NENs therapy