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doi: 10.1186/s13578-021-00657-7 153 LvXGaoFLiTPXuePWangXWanMet al

Store the bottle in a room temperature or refrigerated location

10.1128/msystems.01013-23 Msystems 95 MilaniC.DurantiS.BottaciniF.CaseyE.TurroniF.MahonyJ.et al (2017)

Baar et al, Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

The use of methotrexate may additionally invalidate diagnostic assays for folic acid and vitamin B12

This would lead to knockdown of both of the essential redox systems required to sustain DNA synthesis, and thereby conserve ribonucleotides to enhance RNA synthesis for virus production