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It was developed specifically as a selective secretagogue, designed to trigger GH release while avoiding the hormonal "noise" (cortisol, prolactin) seen with earlier GHRPs

Common side effects: Injection site discomfort Mild diarrhea Hot flashes Dizziness or itching Precautions: Avoid B12 injections if youre allergic to cobalt or have Lebers hereditary optic neuropathy

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Further structure-based iterative optimization resulting in inhibitors shown in Fig

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