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Patents, manufacturing complexity, and high demand contribute to steep prices, especially without insurance

[14] Ergothioneine does this by activating nuclear factor erythroid 2-related factor 2 (Nrf2) , a stress sensor that switches on endogenous cellular antioxidant defenses

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Expert Opin Drug Discovery (2014) 9:122351

Robert Kirsner, professor of dermatology at the University of Miami and past president of the Wound Healing Society, has stated in published commentary: "We have a biological rationale and supportive preclinical data for copper peptides in wound care, but the randomized clinical trial evidence that regulators and guideline bodies require simply has not been generated" [8]

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