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Experiments with recombinant enzyme and FeSOD-overexpressing parasites revealed its importance in virulence and pathogenicity, safeguarding the parasite from host-derived cytotoxic oxidants (Piacenza et al., 2008
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study
Additionally, ROS contribute to metabolic reprogramming in cancer cells, such as the Warburg effect and glutamine metabolism, providing essential energy to sustain rapid growth [40]
A study indicates that vitamin E was able to reduce blood pressure in people suffering from kidney disease
Specifically, the E3 ubiquitin ligase TRIM21 has been shown to facilitate K63-linked ubiquitination of FSP1 at K322 and K366, which disrupts the plasma membrane localization and ferroptosis resistance of FSP1[9]
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