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Similarly, mice lacking NLRP3 or treated with an IL-1 receptor antagonist had smaller rises in ALT/AST and better histology after liver IR (199)
As summarized in Figure 5, these interconnected ROS-driven mechanisms integrate mitochondrial impairment with proteolytic signaling cascades and provide a mechanistic explanation for progressive supraspinatus atrophy following rotator cuff injury
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor J Physiol 1998
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