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Repeated freeze-thaw cycles degrade peptide integrity and should be avoided

A recent study engineered CAR-T cells targeting fibroblast activation protein (FAP), a cell-surface protein overexpressed on activated HSCs, and reported antifibrotic effects across four murine models of liver fibrosis, including MASH-associated fibrosis (181)

Aging, obesity, metabolic stress, and genetic perturbations disrupt these regulatory networks, leading to redox imbalance, impaired oxidative phosphorylation, altered mitochondrial dynamics, and mitochondrial DNA instability

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