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Canadian pharmaceutical pricing typically matches or slightly exceeds US levels

These include itsactions on acetylcholine synthesis, membrane stability, nerve growth factor production, and cerebral blood flow

If monotherapy proves insufficient, clinicians may consider: Optimising the current medication (ensuring proper technique for Saxenda injections, addressing side effects, reinforcing dietary adherence) Switching to an alternative medication rather than adding a second Intensifying lifestyle support through referral to specialist weight management services Evaluating for bariatric surgery in patients meeting criteria (typically BMI 40 kg/m or 35 kg/m with comorbidities, with consideration for people with recent-onset type 2 diabetes at BMI 30-34.9) Combination pharmacotherapy is not standard practice and would typically only be considered by specialists in weight management services after careful evaluation

Eng received a patent for exendin-4 in 1996

J Pharm Sci 1995;84(5):627-633

Compounded semaglutide contains the identical active molecule and is manufactured in licensed 503A pharmacies under strict quality standards