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Depletion of RNF4 exerts antiproliferative effects in AML cells and increased their sensitivity towards antileukemic drugs thus validating RNF4 as a potential vulnerability in AML

In vitro experiments suggest that GSH is a poor substrate for Ero1 (Tu & Weissman, 2002)

Effects of selenium on short-term control of hyperthyroidism due to graves disease treated with methimazole: Results of a randomized clinical trial

If there are excess vitamin B12 left, it will be stored in the liver for future use

While we cannot fully exclude contributions from bacterial number, we primarily used the reporter to infer bacterial metabolic activity and energy state

Common examples include fatigue or low energy with normal blood results, brain fog or reduced concentration without confirmed vitamin B12 deficiency, stress-related exhaustion or burnout, increased metabolic demand such as during illness recovery, high workload, or intense training, restrictive or inconsistent dietary intake, or suspected poor oral absorption despite normal serum levels