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In particular, the inhibition of eNOS results from the PKC phosphorylation of Thr495, amplified by the simultaneous dephosphorylation of Ser-1177 (Figure 1) ( Figure 1 2.3 Other players involved in endothelium-dependent vasodilatation and vasoconstriction Endothelium-derived contraction factors include Ang II, thrombin, thromboxane A2 (TxA2), O 2 , and endothelin 1 (ET-1) ( 2.4 Regulation of the endothelium integrity: the role of endothelial glycocalyx on NO bioavailability Macromolecules can cross the endothelial barrier through cellcell junctions, diffusion, vesicular transport, endothelial gaps, or through the cells themselves

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The effects of trimetazidine on QT-interval prolongation and cardiac hypertrophy in diabetic rats

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Erhardt J et al