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Precautions & Notes AOD9604 activity is concentration- and context-dependent

"Effect of bile on vitamin B12 absorption"

Intramuscular injections may be preferred for deeper absorption , while subcutaneous options may offer ease of use in at-home settings when clinically appropriate

Until recently, there wasnt much we could do to directly regulate NNMT other than make a few lifestyle modifications, which are still important

What FDA has said recently (high-level, patient-friendly summary) FDA maintains a page describing certain bulk drug substances used in compounding that may present significant safety risks, including AOD-9604, noting concerns such as potential immunogenicity and limited safety-related information for some uses/routes

This is essentially done because the body can absorb vitamin B12 through shots without going through the digestive system