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Cagrilintide, a long-acting human amylin analogue, exerts both central and peripheral effects by enhancing satiety, delaying gastric emptying, and modulating postprandial glucagon secretion, whereas semaglutide acts on GLP-1 receptors in the central nervous system and peripheral tissues to regulate appetite, glycemic control, and energy balance

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Furthermore, the study primarily assessed morphological parameters

Hino K, Nishina S, Sasaki K, Hara Y

Mendell JR (1971) Amyotrophic lateral sclerosis: a study of central monoamine metabolism and therapeutic trial of levodopa

B12 supports energy production and metabolism, which can indirectly support weight loss efforts