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Upon its efflux from cells, oxidised glutathione is exposed to the sequential action of enzymes located on the external face of the cell membrane: -glutamyl transpeptidase (GGT) generates glutamate 94 and the cysteinylglycine dipeptide, which is degraded by dipeptidases such as aminopeptidase N (APN), thereby releasing cysteine and glycine

Int J Cell Biol, 2014

Dark spots visibly fade Consistent use over weeks shows continued fading of existing dark spots and a clearer overall complexion

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For most people, topical application of GHK-Cu purchased from a reputable source, paired with microneedling, is the most accessible and the safest avenue

Given the relatively small sample size, the study may have been underpowered to detect modest but biologically meaningful changes