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Because of this and the fact that the body only needs a small amount of vitamin B12 each day, it can take up to a year or even longer for an inadequate vitamin B12 to manifest as an apparent deficiency

"Cobalamin metabolism and its clinical aspects" (PDF)

[172] Another in vitro study, however, shows tamoxifen and genistein synergistically inhibit the growth of estrogen receptor-negative breast cancer cells

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As mentioned, those who eat a vegetable based diet will almost certainly have sufficient levels of glutathione