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Clinical trials of Wegovy (semaglutide) and Zepbound (tirzepatide) show that some weight loss can come from lean mass, the portion of body weight made up of muscle, organs, bones, and water, so musclepreserving support matters

Defronzo, R

custom orthotics or supportive shoes may improve knee biomechanics 5

However, these studies are constrained by small sample sizes, short follow-up periods, and limited generalizability across diverse populations

Decisions about your dose or your treatment belong with the clinician who prescribed it

In fact, insulin therapy can sometimes lead to weight gain, as it helps store excess calories in the form of fat