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The enteric nervous system appears particularly vulnerable, and enteric -syn pathology often precedes motor symptoms, supporting the hypothesis that PD may originate in the gut and propagate to the brain in a transsynaptic prionlike manner [80]

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Xu Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The current level considered sufficient for folate in plasma (i.e