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PLoS ONE 10 , e0131266 (2015)

2009 Sep;161(3):707-8

To test whether they could prolong the response, the team blocked PDE4, a naturally occurring enzyme that breaks down cAMP, using the drug roflumilast

The bad news is that they might last for the entire day, which can ruin productivity and make it feel like youve wasted your weekend

doi: 10.3803/EnM.2014.29.4.536 70 KrnerMStckliMWaserBReubiJC

The DNA sequence spanning the CBS gene ARE motif located 4970 bp upstream of the transcript start site and its mutants were cloned into a GFP expressing reporter pEGFP-N1 (PT3054, Clontech) with sequence specific primers (Supplementary Table 1)