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3 Model based estimates are based on an analysis of covariance (or logistic regression for the 5%, 10%, 15% or 20% achievement endpoints) including treatment as a factor and baseline value as a covariate

References Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE

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His concerns were the gaunt appearance and premature ageing, which developed progressively during the course of therapy