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The FDA has approved the following prescription weight loss pills for chronic weight management: Phentermine/topiramate (Qsymia) , taken once daily

Since semaglutide further slows gastric emptying as part of its mechanism of action, patients with pre-existing gastroparesis may experience worsening of symptoms including nausea, vomiting, bloating, and abdominal discomfort

It is the first oral small molecule GLP-1 drug to successfully complete phase 3 trials, producing average weight losses of 8% after 40 weeks, and 12% at 72 weeks

Note: Compounded medications are prepared in FDA-registered and inspected compounding pharmacies, but they are not themselves FDA-approved

The results reflect what the ingredient can do when absorption is optimised, which is a meaningful qualifier

For those on GLP-1 therapy, especially older adults or individuals engaging in any form of resistance training, creatine may be a valuable addition to support healthy, sustainable weight loss