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Clinical Factors That Influence Medication Selection and Cost Patient metabolic profile, insulin sensitivity, and baseline glucose levels guide whether monotherapy (semaglutide alone) or dual-agent therapy (tirzepatide or GLP-Squared) is clinically appropriate

Non-alcoholic fatty liver disease (NAFLD) : Emerging evidence suggests potential benefits in reducing hepatic inflammation, though this remains an area of ongoing research and is not a licensed indication

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Adding to the mounting reasons why HCPs choose Wegovy , the FDA expanded the label in 2024 to include an indication for reduction of the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight

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