Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype
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It suggests theres an additive effect of these two medications, said Andrew Saxon, an addiction psychiatrist at the University of Washington who was not involved with this study, potentially because liraglutide and buprenorphine target different mechanisms
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Semaglutide works by mimicking a hormone in the body called GLP-1, which helps to control blood sugar levels and reduce appetite