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Adding up to all this, there may also be a central insulin resistance during pregnancy in certain specific regions of the hypothalamus, such as the arcuate nucleus, a major site of action of insulin, therefore altering transiently the brain sensitivity to that specific hormone [172]

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Despite the known photoprotective effects of MT-II which are hypothesized to reduce the risks of skin cancer, concerns have paradoxically been raised about a potential cancer risk following publication of an anecdotal case study in which development of melanoma was observed in a patient who used MT-II [25]

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