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Early Phase 2 data suggest substantial weight loss, though it is important to note that no direct head-to-head trials comparing retatrutide with tirzepatide or other agents have been conducted

This is the mechanism behind semaglutide, tirzepatide, and every other GLP-1 agonist on the market

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New Trends Med Sci 1:9499 Yoshioka H, Nonogaki T, Ohnishi H et al (2018) 1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice

Because safety hasn't been established, the standard advice is to skip it while pregnant or nursing unless a doctor says otherwise (WebMD)

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