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We will dig deeper into these business model concerns later in this guide

Rushing through the initial phase to reach higher doses faster typically backfires through increased side effects and potential discontinuation

On the other hand, the use of animal models to study invasive meningococcal disease, in addition to presenting the obvious difficulties in investigating aspects of the extracellular/intracellular phase of meningococcal infection, is hampered by the fact that meningococcus has a very narrow host specificity, essentially restricted to humans

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For instance, children with severe vitamin E deficiency at birth rapidly experience irreversible neurologic symptoms if not treated with vitamin E