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Exogenous GLP-1 RAs At normal physiological levels, active GLP-1 levels peak around 30-60 minutes after ingesting a meal before being rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

However, the most significant difference is between systemic circulation (minutes) and topical application on the skin (hours of local residence time)

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Some patients do make this switch under medical supervision