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Studies have shown that Complex I activity is diminished in both post-mortem brain tissue and peripheral blood cells of PD patients ( Previous studies have shown that mitochondrial dysfunction related to PD can be caused by various factors, including mitochondrial bio-genetic defects, increased ROS production, mitophagy defects, transport disorders, electron transport chain dysfunction, mitochondrial dynamics changes, and mitochondrial calcium imbalance

doi: 10.1016/j.tem.2016.03.017 81 SlleyEKunSSzijrtIAKertszMWittmannIMolnrGA

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respectively) (Table 5)

Many patients prefer weekend days when they have fewer time pressures, whilst others choose a weekday that aligns with other regular commitments