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Moreover, DNase-I-coated nanospheres decreased eDNA concentrations in the blood, neutrophil activity, lung damage and mortality in a septic mouse model (119)

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While the clinical impact varies, it is important to consider timing and dosing adjustments

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Later on, the FDA withdrew its approval in 2008 because of commercial reasons unrelated to its safety and efficacy

8 SUMMIT also demonstrated significant improvements in patient-reported outcomes: at 52 weeks, tirzepatide increased KCCQ-CSS, with a between-group mean difference of 6.9 points, and increased 6-minute walk distance, with a between-group mean difference of 18.3 m